Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1.

Epithelial cell adhesionmolecule (EpCAM) is overexpressed in 55%-75% of ovarian carcinomas (OC). EpCAM might be used as a target for a treatment of disseminated OC. Designed ankyrin repeats protein (DARPin) Ec1 is a small (18 kDa) protein, which binds to EpCAM with subnanomolar affinity. We tested a hypothesis that Ec1 labeled with a non-residualizing label might serve as a companion imaging diagnostic for stratification of patients for EpCAM-targeting therapy.

Ec1 was labeled with ¹²⁵I using N-succinimidyl-para-iodobenzoate. Binding affinity, specificity, and cellular processing of [¹²⁵I]I-PIB-Ec1 were evaluated using SKOV-3 and OVCAR-3 ovarian carcinoma cell lines. Biodistribution and tumor-targeting properties of [¹²⁵I]I-PIB-Ec1 were studied in Balb/c nu/nu mice bearing SKOV-3 and OVCAR-3 xenografts. EpCAM-negative Ramos lymphoma xenografts served as specificity control. Binding of [¹²⁵I]I-PIB-Ec1 to ovarian carcinoma cell lines was highly specific and had affinity in picomolar range.

Slow internalization of [¹²⁵I]I-PIB-Ec1 by OC cells confirmed utility of non-residualizing label for in vivo imaging. [¹²⁵I]I-PIB-Ec1 provided 6 h after injection tumor-to-blood ratios of 30 ± 11 and 48 ± 12 for OVCAR-3 and SKOV-3 xenografts, respectively, and high contrast to other organs. Tumor targeting was highly specific.

Mouse SKT shRNA Plasmid
20-abx980555	Abbexa	EUR 801.00 EUR 1121.00	150 µg 300 µg

Mouse Sickle tail protein (SKT) ELISA Kit
abx389166-96tests	Abbexa	96 tests	EUR 911

Mouse Sickle tail protein, Skt ELISA KIT
ELI-29595m	Lifescience Market	96 Tests	EUR 865

CD14 Recombinant Protein
96-108	ProSci	0.1 mg	EUR 516.5
Description: Cluster of differentiation 14 (CD14), is a cell surface glycoprotein, and is a is a component of the innate immune system. CD14 is a myelomonocytic differentiation antigen preferentially expressed on monocytes, macrophages, and activated granulocytes. CD14 exists in two forms. Either it is anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 kDa) or is directly secreted from intracellular vesicles (56 kDa). CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS). CD14 can bind LPS only in the presence of lipopolysaccharide-binding protein (LBP). CD14 has been proposed to be involved in various biological processes, including transportation of other lipids, cell-cell interaction during different immune responses, as well as recognition of apoptotic cells. Although LPS is considered its main ligand, CD14 also recognizes other pathogen-associated molecular patterns. CD14+ cells are monocytes that can differentiate into a host of different cells. CD14 has been shown to interact with Lipopolysaccharide-binding protein.

RG 108
A1913-10	ApexBio	10 mg	EUR 119
Description: RG108 is a DNA methyltransferase (DMNT) inhibitor that enhanced reprogramming of OK-transduced MEFs in the presence of BIX. It is a small molecule that effectively blocked DNA methyltransferases in vitro and did not cause covalent enzyme trapping in human cell lines.

RG 108
A1913-25	ApexBio	25 mg	EUR 166
Description: RG108 is a DNA methyltransferase (DMNT) inhibitor that enhanced reprogramming of OK-transduced MEFs in the presence of BIX. It is a small molecule that effectively blocked DNA methyltransferases in vitro and did not cause covalent enzyme trapping in human cell lines.

RG 108
A1913-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 119
Description: RG108 is a DNA methyltransferase (DMNT) inhibitor that enhanced reprogramming of OK-transduced MEFs in the presence of BIX. It is a small molecule that effectively blocked DNA methyltransferases in vitro and did not cause covalent enzyme trapping in human cell lines.

RG 108
1679-10	Biovision		EUR 180

RG 108
1679-30	Biovision		EUR 359

Glucose M9Y
108	AthenaES	500 g	EUR 84

Human Sickle tail protein homolog, SKT ELISA KIT
ELI-18163h	Lifescience Market	96 Tests	EUR 824

Angiogenin (108-122)
HY-P1516	MedChemExpress	10mg	EUR 980

Angiogenin (108-122)
5-00673	CHI Scientific	4 x 1mg	Ask for price

Angiogenin (108-123)
5-00674	CHI Scientific	4 x 1mg	Ask for price

Angiogenin (108-123)
H-8020.0001	Bachem	1.0mg	EUR 441
Description: Sum Formula: C83H132N26O24; CAS# [112173-48-5]

Angiogenin (108-123)
H-8020.0005	Bachem	5.0mg	EUR 1675
Description: Sum Formula: C83H132N26O24; CAS# [112173-48-5]

Angiogenin (108-122)
H-8095.0001	Bachem	1.0mg	EUR 212
Description: Sum Formula: C78H125N25O23; CAS# [112173-49-6]

Angiogenin (108-122)
H-8095.0005	Bachem	5.0mg	EUR 756
Description: Sum Formula: C78H125N25O23; CAS# [112173-49-6]

hCRP FRET 96
CH1021-96	Mediomics	1 Kit	EUR 455

hCRP TRF 96
CHTR1021-96	Mediomics	1 Kit	EUR 482

hAlbumin FRET 96
AH1005-96	Mediomics	1 Kit	EUR 455

hAlbumin TRF 96
AHTR1005-96	Mediomics	1 Kit	EUR 482

hInsulin FRET 96
IH1017-96	Mediomics	1 Kit	EUR 455

hInsulin TRF 96
IHTR1017-96	Mediomics	1 Kit	EUR 482

rIgG FRET 96
RI1024-96	Mediomics	1 Kit	EUR 455

mIgG TRF 96
MIGTR1020-96	Mediomics	1 Kit	EUR 482

Skt ELISA Kit| Mouse Sickle tail protein ELISA Kit
EF014796	Lifescience Market	96 Tests	EUR 689

Acrp30 (108-244) Adiponectin (108-244 a.a.) Human Recombinant Protein
PROTQ15848-1	BosterBio	Regular: 25ug	EUR 317
Description: Acrp30 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 158 amino acids (108-244 a.a.) and having a molecular mass of 18.1kDa.;Acrp30 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Angiogenin (108-122) (TFA)
HY-P1516A	MedChemExpress	10mM/1mL	EUR 1988

HIST1H2BC (Ab-108) Antibody
1-CSB-PA010403OA108nacHU	Cusabio	EUR 332.00 EUR 335.00	100ul 50ul
Description: A polyclonal antibody against HIST1H2BC (Ab-108). Recognizes HIST1H2BC (Ab-108) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200

HIST1H2BC (Ab-108) Antibody
1-CSB-PA010403OA108nforHU	Cusabio	EUR 332.00 EUR 335.00	100ul 50ul
Description: A polyclonal antibody against HIST1H2BC (Ab-108). Recognizes HIST1H2BC (Ab-108) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IP; Recommended dilution: WB:1:200-1:2000, IHC:1:10-1:100, IP:1:200-1:2000

HIST1H2BC (Ab-108) Antibody
1-CSB-PA010403OA108nhibHU	Cusabio	EUR 332.00 EUR 335.00	100ul 50ul
Description: A polyclonal antibody against HIST1H2BC (Ab-108). Recognizes HIST1H2BC (Ab-108) from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, ChIP; Recommended dilution: WB:1:200-1:2000

Anti-IGKV1OR2-108 (3A11)
YF-MA20540	Abfrontier	100 ug	EUR 363
Description: Mouse monoclonal to IGKV1OR2-108

Rat Coiled coil domain containing protein 108(CCDC108) ELISA kit
E02C1011-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Coiled coil domain containing protein 108(CCDC108) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Coiled coil domain containing protein 108(CCDC108) ELISA kit
E03C1011-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Coiled coil domain containing protein 108(CCDC108) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Coiled coil domain containing protein 108(CCDC108) ELISA kit
E08C1011-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Canine Coiled coil domain containing protein 108(CCDC108) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Coiled coil domain containing protein 108(CCDC108) ELISA kit
E06C1011-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Coiled coil domain containing protein 108(CCDC108) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Coiled coil domain containing protein 108(CCDC108) ELISA kit
E04C1011-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Coiled coil domain containing protein 108(CCDC108) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Coiled coil domain containing protein 108(CCDC108) ELISA kit
E07C1011-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Coiled coil domain containing protein 108(CCDC108) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Coiled coil domain containing protein 108(CCDC108) ELISA kit
E01C1011-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Human Coiled coil domain containing protein 108(CCDC108) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Coiled coil domain containing protein 108(CCDC108) ELISA kit
E09C1011-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Coiled coil domain containing protein 108(CCDC108) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

HSC70 ELISA Kit
SKT-106-96	Stressmarq	1 plate of 96 wells	EUR 717
Description: Sandwich ELISA kit used for quantitate HSC70 concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Avian

HSP90 alpha ELISA Kit
SKT-107-96	Stressmarq	1 plate of 96 wells	EUR 685
Description: Sandwich ELISA kit used for quantitate HSP90 alpha concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Goat, Avian

HSP27 ELISA Kit
SKT-109-96	Stressmarq	1 plate of 96 wells	EUR 585
Description: Sandwich ELISA kit used for quantitate HSP27 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human

HSP60 ELISA Kit
SKT-110-96	Stressmarq	1 plate of 96 wells	EUR 585
Description: Sandwich ELISA kit used for quantitate HSP60 concentration in Cell Lysates, Tissue, Serum samples from Human

HO-1 ELISA Kit
SKT-111-96	Stressmarq	1 plate of 96 wells	EUR 585
Description: Sandwich ELISA kit used for quantitate HO-1 concentration in Cell Lysates, Tissue, Serum, Cyst fluid samples from Human, Rat

HSP65 ELISA Kit
SKT-113-96	Stressmarq	1 plate of 96 wells	EUR 633
Description: Sandwich ELISA kit used for quantitate M bovis/M tuberculosum HSP65 concentration in human samples in Cell Lysates, Tissue, Serum samples from M bovis, M tuberculosum

Alpha B Crystallin ELISA Kit
SKT-123-96	Stressmarq	1 plate of 96 wells	EUR 717
Description: Sandwich ELISA kit used for quantitate alpha B crystallin concentration in Cell Lysates, Tissue, Serum samples from Human

HSP70 ELISA Kit (PLANT)
SKT-124-96	Stressmarq	1 plate of 96 wells	EUR 717
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Plant extract, Cell Lysates, Tissue, Serum, Plasma samples from Plant, Human

Nitrotyrosine ELISA Kit
SKT-126-96	Stressmarq	1 plate of 96 wells	EUR 460
Description: Competitive ELISA kit used for quantitate Nitrotyrosine in Plasma, Serum, Cell Lysates, Urine samples from all species

Rat GRP78 ELISA Kit
SKT-137-96	Stressmarq	1 plate of 96 wells	EUR 632
Description: Sandwich ELISA kit used for quantitate GRP78 concentration in rat samples in Tissue samples from Rat

Dibromo-tyrosine ELISA Kit
SKT-140-96	Stressmarq	1 plate of 96 wells	EUR 566
Description: Competitive ELISA kit used to quantify free and protein-bound 3,5-dibromotyrosine in Plasma, Urine samples from all species

Cortisol EIA Kit
SKT-201-96	Stressmarq	1 plate of 96 wells	EUR 329
Description: Competitive EIA kit used for quantitative measuring cortisol present in Dried Fecal Samples, Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Glutathione Detection Kit
SKT-202-96	Stressmarq	1 plate of 96 wells	EUR 428
Description: Direct Fluorometric detection assay to measure the total GSH content in Whole Blood, Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Urine, Cell Lysates, Tissue samples from all species

Glutathione S-Transferase Activity Kit
SKT-203-96	Stressmarq	1 plate of 96 wells	EUR 428
Description: Enzyme Activity Fluorometric assay used for quantitative measuring the activity of glutathione S-transferase in Urine, Serum, EDTA Plasma, Heparin Plasma, Cell Lysates samples from Human, Mollusk, Fish

Glutathione Reductase Activity Kit
SKT-204-96	Stressmarq	1 plate of 96 wells	EUR 428
Description: Enzyme Activity Fluorometric assay used for measuring glutathione reductase activity by the amount of GSH generated from the reduction of GSSG, in Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Cell Lysates samples from Human

Corticosterone EIA Kit
SKT-205-96	Stressmarq	1 plate of 96 wells	EUR 355
Description: Sandwich EIA kit used to measure the corticosterone present in Serum, EDTA Plasma, Heparin Plasma, Urine, Tissue Culture Media, Dried Fecal Samples samples from all species

Cortisone CLIA Kit
SKT-206-96	Stressmarq	1 plate of 96 wells	EUR 467
Description: Sandwich CLIA kit used for quantitative measuring the cortisone present in Dried Fecal Samples, Serum, Saliva, Urine, Plasma, Tissue Culture Media samples from all species

Prostaglandin E2 EIA Kit
SKT-207-96	Stressmarq	1 plate of 96 wells	EUR 527
Description: Sandwich EIA kit used for quantitative measuring PGE2 present in Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic AMP CLIA Kit (High-Sensitivity)
SKT-208-96	Stressmarq	1 plate of 96 wells	EUR 494
Description: Direct CLIA kit used for quantitative measuring cAMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic AMP EIA Kit
SKT-209-96	Stressmarq	1 plate of 96 wells	EUR 454
Description: Direct EIA kit used for quantitative measuring cAMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic GMP CLIA Kit (High-Sensitivity)
SKT-210-96	Stressmarq	1 plate of 96 wells	EUR 520
Description: Direct CLIA kit used to measure cGMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Tissue Culture Media samples from all species

Cyclic GMP EIA Kit
SKT-211-96	Stressmarq	1 plate of 96 wells	EUR 474
Description: Direct EIA kit used for quantitative measuring cGMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Tissue Culture Media samples from all species

Nitric Oxide Detection Kit
SKT-212-96	Stressmarq	2 plates of 96 wells	EUR 342
Description: Indirect Colorimetric assay used for quantitative measuring Nitrate and Nitrite present in a variety of samples in Serum, Plasma, Urine, Saliva, Water, Buffer, Cell Lysates, Tissue Culture Media samples from all species

Retinol Binding Protein Urinary EIA Kit
SKT-218-96	Stressmarq	1 plate of 96 wells	EUR 527
Description: Sandwich EIA kit used to measure RBP levels in urine samples in Urine samples from Human, Rat, Dog, Monkey

Cystatin C EIA Kit
SKT-219-96	Stressmarq	1 plate of 96 wells	EUR 494
Description: Sandwich EIA kit used to measure cystatin C levels in Serum, EDTA Plasma, Heparin Plasma, Urine, Tissue Culture Media samples from Human

HSP70 ELISA Kit
SKT-105-96	Cusabio	1 plate of 96 wells	EUR 581
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Cell Lysates, Tissue, Serum, Urine samples from Human, Goat, Dog

Tissue Culture Plate, 96 Well
TCP20-96	Bio Basic	1 UNIT	EUR 53.48

Aligned Nanofibers 96 Well Plate
3D00012-96	Neuromics	700 nm-PCLs	EUR 110

Bridge-It cAMP-PDE 96
PD1016-96	Mediomics	1 Kit	EUR 455

Guinea pig Coiled coil domain containing protein 108(CCDC108) ELISA kit
E05C1011-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Guinea pig Coiled coil domain containing protein 108(CCDC108) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Transmembrane Protein 108 (TMEM108) Antibody
20-abx116235	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Transmembrane Protein 108 (TMEM108) Antibody
abx034435-400ul	Abbexa	400 ul	EUR 523

Transmembrane Protein 108 (TMEM108) Antibody
abx034435-80l	Abbexa	80 µl	EUR 286

MHC I(108-2C5) Antibody
BNCA1095-250	Biotium	250uL	EUR 383
Description: Primary antibody against MHC I(108-2C5), APC conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNC811095-100	Biotium	100uL	EUR 199
Description: Primary antibody against MHC I(108-2C5), CF680R conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNC811095-500	Biotium	500uL	EUR 544
Description: Primary antibody against MHC I(108-2C5), CF680R conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNCAP1095-100	Biotium	100uL	EUR 199
Description: Primary antibody against MHC I(108-2C5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNCAP1095-500	Biotium	500uL	EUR 544
Description: Primary antibody against MHC I(108-2C5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNCB1095-100	Biotium	100uL	EUR 199
Description: Primary antibody against MHC I(108-2C5), Biotin conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNCB1095-500	Biotium	500uL	EUR 544
Description: Primary antibody against MHC I(108-2C5), Biotin conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNC471095-100	Biotium	100uL	EUR 199
Description: Primary antibody against MHC I(108-2C5), CF647 conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNC471095-500	Biotium	500uL	EUR 544
Description: Primary antibody against MHC I(108-2C5), CF647 conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNC551095-100	Biotium	100uL	EUR 199
Description: Primary antibody against MHC I(108-2C5), CF555 conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNC551095-500	Biotium	500uL	EUR 544
Description: Primary antibody against MHC I(108-2C5), CF555 conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNC431095-100	Biotium	100uL	EUR 199
Description: Primary antibody against MHC I(108-2C5), CF543 conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNC431095-500	Biotium	500uL	EUR 544
Description: Primary antibody against MHC I(108-2C5), CF543 conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNC881095-100	Biotium	100uL	EUR 199
Description: Primary antibody against MHC I(108-2C5), CF488A conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNC881095-500	Biotium	500uL	EUR 544
Description: Primary antibody against MHC I(108-2C5), CF488A conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNC941095-100	Biotium	100uL	EUR 199
Description: Primary antibody against MHC I(108-2C5), CF594 conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNC941095-500	Biotium	500uL	EUR 544
Description: Primary antibody against MHC I(108-2C5), CF594 conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNCH1095-100	Biotium	100uL	EUR 199
Description: Primary antibody against MHC I(108-2C5), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNCH1095-500	Biotium	500uL	EUR 544
Description: Primary antibody against MHC I(108-2C5), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNCP1095-250	Biotium	250uL	EUR 383
Description: Primary antibody against MHC I(108-2C5), PerCP conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNC041095-100	Biotium	100uL	EUR 199
Description: Primary antibody against MHC I(108-2C5), CF405S conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody
BNC041095-500	Biotium	500uL	EUR 544
Description: Primary antibody against MHC I(108-2C5), CF405S conjugate, Concentration: 0.1mg/mL

Saturation of tumor uptake at a high dose of Ec1 in SKOV-3 model provided a rationale for dose selection in further studies using therapeutic conjugates of Ec1 for targeted therapy. In conclusion, [¹²⁵I]I-PIB-Ec1 is a promising agent for visualizing EpCAM expression in OC.