Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1.

Epithelial cell adhesionmolecule (EpCAM) is overexpressed in 55%-75% of ovarian carcinomas (OC). EpCAM might be used as a target for a treatment of disseminated OC. Designed ankyrin repeats protein (DARPin) Ec1 is a small (18 kDa) protein, which binds to EpCAM with subnanomolar affinity. We tested a hypothesis that Ec1 labeled with a non-residualizing label might serve as a companion imaging diagnostic for stratification of patients for EpCAM-targeting therapy.

Ec1 was labeled with 125I using N-succinimidyl-para-iodobenzoate. Binding affinity, specificity, and cellular processing of [125I]I-PIB-Ec1 were evaluated using SKOV-3 and OVCAR-3 ovarian carcinoma cell lines. Biodistribution and tumor-targeting properties of [125I]I-PIB-Ec1 were studied in Balb/c nu/nu mice bearing SKOV-3 and OVCAR-3 xenografts. EpCAM-negative Ramos lymphoma xenografts served as specificity control. Binding of [125I]I-PIB-Ec1 to ovarian carcinoma cell lines was highly specific and had affinity in picomolar range.

Slow internalization of [125I]I-PIB-Ec1 by OC cells confirmed utility of non-residualizing label for in vivo imaging. [125I]I-PIB-Ec1 provided 6 h after injection tumor-to-blood ratios of 30 ± 11 and 48 ± 12 for OVCAR-3 and SKOV-3 xenografts, respectively, and high contrast to other organs. Tumor targeting was highly specific.

Mouse Sickle tail protein (SKT) ELISA Kit

abx389166-96tests 96 tests
EUR 1093.2

Mouse Sickle tail protein, Skt ELISA KIT

ELI-29595m 96 Tests
EUR 1038

Human Sickle tail protein homolog, SKT ELISA KIT

ELI-18163h 96 Tests
EUR 988.8

Skt ELISA Kit| Mouse Sickle tail protein ELISA Kit

EF014796 96 Tests
EUR 826.8

RG 108

1679-10 each
EUR 216

RG 108

1679-30 each
EUR 430.8

RG 108

A1913-10 10 mg
EUR 48
Description: DNA methyltransferase inhibitor

RG 108

A1913-25 25 mg
EUR 80
Description: DNA methyltransferase inhibitor

RG 108

A1913-5.1 10 mM (in 1mL DMSO)
EUR 48
Description: DNA methyltransferase inhibitor

NVX-108

T33765-10mg 10mg Ask for price
Description: NVX-108

NVX-108

T33765-1g 1g Ask for price
Description: NVX-108

NVX-108

T33765-1mg 1mg Ask for price
Description: NVX-108

NVX-108

T33765-50mg 50mg Ask for price
Description: NVX-108

NVX-108

T33765-5mg 5mg Ask for price
Description: NVX-108

AFK-108

T23655-10mg 10mg Ask for price
Description: AFK-108

AFK-108

T23655-1g 1g Ask for price
Description: AFK-108

AFK-108

T23655-1mg 1mg Ask for price
Description: AFK-108

AFK-108

T23655-50mg 50mg Ask for price
Description: AFK-108

AFK-108

T23655-5mg 5mg Ask for price
Description: AFK-108

PIK-108

T28416-10mg 10mg Ask for price
Description: PIK-108

PIK-108

T28416-1g 1g Ask for price
Description: PIK-108

PIK-108

T28416-1mg 1mg Ask for price
Description: PIK-108

PIK-108

T28416-50mg 50mg Ask for price
Description: PIK-108

PIK-108

T28416-5mg 5mg Ask for price
Description: PIK-108

RG-108

abx282703-100g 100 µg Ask for price

RG-108

abx282703-20g 20 µg
EUR 118.75

RG-108

abx282703-50g 50 µg
EUR 300

Hsp-108

110081 each
EUR 249
Description: Human

Musclin (108-133) / Osteocrin (Ostn) (108-133) (Human)

028-64 100 μg
EUR 140.4

Angiogenin (108-122)

5-00673 4 x 1mg Ask for price

Angiogenin (108-123)

5-00674 4 x 1mg Ask for price

Acrp30 (108-244)

cyt-073 5µg
EUR 60
Description: Recombinant Human Adiponectin (108-244 a.a.)

BP-1-108

B676705 250mg
EUR 12800
Description: 1334492-85-1

Angiogenin (108-122)

HY-P1516 10mg
EUR 1176

Angiogenin (108-123)

H-8020.0001 1.0mg
EUR 529.2
Description: Sum Formula: C83H132N26O24; CAS# [112173-48-5]

Angiogenin (108-123)

H-8020.0005 5.0mg
EUR 2010
Description: Sum Formula: C83H132N26O24; CAS# [112173-48-5]

Angiogenin (108-122)

H-8095.0001 1.0mg
EUR 254.4
Description: Sum Formula: C78H125N25O23; CAS# [112173-49-6]

Angiogenin (108-122)

H-8095.0005 5.0mg
EUR 907.2
Description: Sum Formula: C78H125N25O23; CAS# [112173-49-6]

SNX2-1-108

T24811-10mg 10mg Ask for price
Description: SNX2-1-108

SNX2-1-108

T24811-1g 1g Ask for price
Description: SNX2-1-108

SNX2-1-108

T24811-1mg 1mg Ask for price
Description: SNX2-1-108

SNX2-1-108

T24811-50mg 50mg Ask for price
Description: SNX2-1-108

SNX2-1-108

T24811-5mg 5mg Ask for price
Description: SNX2-1-108

Angiogenin (108-122)

TP1362-10mg 10mg Ask for price
Description: Angiogenin (108-122)

Angiogenin (108-122)

TP1362-1g 1g Ask for price
Description: Angiogenin (108-122)

Angiogenin (108-122)

TP1362-1mg 1mg Ask for price
Description: Angiogenin (108-122)

Angiogenin (108-122)

TP1362-50mg 50mg Ask for price
Description: Angiogenin (108-122)

Angiogenin (108-122)

TP1362-5mg 5mg Ask for price
Description: Angiogenin (108-122)

Acrp30 (108-244) Adiponectin (108-244 a.a.) Human Recombinant Protein

PROTQ15848-1 Regular: 25ug
EUR 380.4
Description: Acrp30 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 158 amino acids (108-244 a.a.) and having a molecular mass of 18.1kDa.;Acrp30 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Musclin (108-133) / Osteocrin (Ostn) (108-133) (Human) - Biotin Labeled

B-028-64 10 μg
EUR 469.8

Musclin (108-133) / Osteocrin (Ostn) (108-133) (Human) - Cy3 Labeled

FC3-028-64 1 nmol
EUR 840.24

Musclin (108-133) / Osteocrin (Ostn) (108-133) (Human) - FAM Labeled

FG-028-64A 1 nmol
EUR 469.8

Musclin (108-133) / Osteocrin (Ostn) (108-133) (Human) - Rhodamine Labeled

FR-028-64 1 nmol
EUR 469.8

HIST1H2BC (Ab-108) Antibody

1-CSB-PA010403OA108nacHU
  • Ask for price
  • Ask for price
  • 100ul
  • 50ul
Description: A polyclonal antibody against HIST1H2BC (Ab-108). Recognizes HIST1H2BC (Ab-108) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200

HIST1H2BC (Ab-108) Antibody

1-CSB-PA010403OA108nforHU
  • Ask for price
  • Ask for price
  • 100ul
  • 50ul
Description: A polyclonal antibody against HIST1H2BC (Ab-108). Recognizes HIST1H2BC (Ab-108) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IP; Recommended dilution: WB:1:200-1:2000, IHC:1:10-1:100, IP:1:200-1:2000

HIST1H2BC (Ab-108) Antibody

1-CSB-PA010403OA108nhibHU
  • Ask for price
  • Ask for price
  • 100ul
  • 50ul
Description: A polyclonal antibody against HIST1H2BC (Ab-108). Recognizes HIST1H2BC (Ab-108) from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, ChIP; Recommended dilution: WB:1:200-1:2000

Angiogenin (108-122) (TFA)

HY-P1516A 10mM/1mL
EUR 2385.6

Human proBNP (1-108)

GWB-D076CB 0.01 mg Ask for price

Anti-IGKV1OR2-108 (3A11)

YF-MA20540 100 ug
EUR 435.6
Description: Mouse monoclonal to IGKV1OR2-108

Resistin (51-108) (Human)

028-40 20 μg
EUR 282.96

C6orf57 (51-108) (Human)

041-51 100 μg
EUR 405

Angiogenin (108-122) Peptide

abx266668-1ml 1 ml
EUR 375

Angiogenin (108-122) Peptide

abx266668-200l 200 µl
EUR 200

Angiogenin (108-123) Peptide

abx266706-1ml 1 ml
EUR 387.5

Angiogenin (108-123) Peptide

abx266706-200l 200 µl
EUR 200

Transmembrane Protein 108 (TMEM108) Antibody

20-abx116235
  • Ask for price
  • Ask for price
  • 150 ul
  • 50 ul

Cytochrome c fragment (93-108)

A1062-1 1 mg
EUR 60
Description: Initiates apoptosis

Cytochrome c fragment (93-108)

A1062-10 10 mg
EUR 300
Description: Initiates apoptosis

Cytochrome c fragment (93-108)

A1062-25 25 mg
EUR 420
Description: Initiates apoptosis

Cytochrome c fragment (93-108)

A1062-5 5 mg
EUR 180
Description: Initiates apoptosis

Transmembrane Protein 108 (TMEM108) Antibody

abx034435-400ul 400 ul
EUR 627.6

Transmembrane Protein 108 (TMEM108) Antibody

abx034435-80l 80 µl
EUR 343.2

Adiponectin (108-244 a.a.) Protein

20-abx261717
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 mg
  • 25 ug
  • 5 ug

Transmembrane Protein 108 (TMEM108) Antibody

abx238746-100ug 100 ug
EUR 661.2

MHC I(108-2C5) Antibody

BNC811095-100 100uL
EUR 238.8
Description: Primary antibody against MHC I(108-2C5), CF680R conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody

BNC811095-500 500uL
EUR 652.8
Description: Primary antibody against MHC I(108-2C5), CF680R conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody

BNC801095-100 100uL
EUR 238.8
Description: Primary antibody against MHC I(108-2C5), CF680 conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody

BNC801095-500 500uL
EUR 652.8
Description: Primary antibody against MHC I(108-2C5), CF680 conjugate, Concentration: 0.1mg/mL

EZSolution? RG-108, Sterile-filtered

B2238-5 each
EUR 235.2

MHC I(108-2C5) Antibody

BNC431095-100 100uL
EUR 238.8
Description: Primary antibody against MHC I(108-2C5), CF543 conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody

BNC431095-500 500uL
EUR 652.8
Description: Primary antibody against MHC I(108-2C5), CF543 conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody

BNC551095-100 100uL
EUR 238.8
Description: Primary antibody against MHC I(108-2C5), CF555 conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody

BNC551095-500 500uL
EUR 652.8
Description: Primary antibody against MHC I(108-2C5), CF555 conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody

BNC701095-100 100uL
EUR 238.8
Description: Primary antibody against MHC I(108-2C5), CF770 conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody

BNC701095-500 500uL
EUR 652.8
Description: Primary antibody against MHC I(108-2C5), CF770 conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody

BNC611095-100 100uL
EUR 238.8
Description: Primary antibody against MHC I(108-2C5), CF660R conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody

BNC611095-500 500uL
EUR 652.8
Description: Primary antibody against MHC I(108-2C5), CF660R conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody

BNCP1095-250 250uL
EUR 459.6
Description: Primary antibody against MHC I(108-2C5), PerCP conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody

BNCR1095-250 250uL
EUR 459.6
Description: Primary antibody against MHC I(108-2C5), RPE conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody

BNCA1095-250 250uL
EUR 459.6
Description: Primary antibody against MHC I(108-2C5), APC conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody

BNCH1095-100 100uL
EUR 238.8
Description: Primary antibody against MHC I(108-2C5), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody

BNCH1095-500 500uL
EUR 652.8
Description: Primary antibody against MHC I(108-2C5), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody

BNCAP1095-100 100uL
EUR 238.8
Description: Primary antibody against MHC I(108-2C5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

MHC I(108-2C5) Antibody

BNCAP1095-500 500uL
EUR 652.8
Description: Primary antibody against MHC I(108-2C5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

UHRF1 (108-286), GST-tag

55003 100 µg
EUR 460
Description: Tandem Tudor Domain region (a.a. 108-286) of human ubiquitin-like with PHD and ring finger domains 1 (UHRF1), GenBank Accession #NM_001048201, with N-terminal GST-tag, MW = 47.5 kDa, expressed in an E. coli cell expression system.

UHRF1 (108-286), His-tag

55004 100 µg
EUR 460
Description: Tandem Tudor Domain region (a.a. 108-286) of human ubiquitin-like with PHD and ring finger domains 1 (UHRF1), GenBank Accession #NM_001048201, with N-terminal His-tag, MW = 21.6 kDa, expressed in an E. coli cell expression system.

Human proBNP (a.a. 1-108)

GWB-5C1438 0.05 mg Ask for price

OAAL00649-100UG - IGKV1OR2-108 Antibody

OAAL00649-100UG 100ug
EUR 349

IGKV1OR2-108 Recombinant Protein (Human)

RP065016 100 ug Ask for price

Anti-mAPCS (aa97-108) antibody

STJ72695 100 µg
EUR 312

Cytochrome c fragment (93-108)

TP2237-10mg 10mg Ask for price
Description: Cytochrome c fragment (93-108)

Cytochrome c fragment (93-108)

TP2237-1g 1g Ask for price
Description: Cytochrome c fragment (93-108)

Cytochrome c fragment (93-108)

TP2237-1mg 1mg Ask for price
Description: Cytochrome c fragment (93-108)

Cytochrome c fragment (93-108)

TP2237-50mg 50mg Ask for price
Description: Cytochrome c fragment (93-108)

Cytochrome c fragment (93-108)

TP2237-5mg 5mg Ask for price
Description: Cytochrome c fragment (93-108)

Recombinant ASFV War-108 Protein

VAng-1044Lsx-inquire inquire Ask for price
Description: African swine fever virus (isolate Warthog/Namibia/Wart80/1980) Virus attachment protein p12 (War-108), partial, recombinant protein from E. coli. (Uniprot ID: P0C9Y4)

WM-108-PK AB Labels

010108 Pack of 625 Label(s)
EUR 56.4
Description: Description Dutch: Draadmerkernummers op kaart; Description French: Cartes de repères de fils - Chiffres

Transmembrane Protein 108 (TMEM108) Antibody

abx116235-100g 100 µg Ask for price

Transmembrane Protein 108 (TMEM108) Antibody

abx116235-10g 10 µg
EUR 612.5

Transmembrane Protein 108 (TMEM108) Antibody

abx116235-200g 200 µg Ask for price

prepro-Augurin (108-132) (Human)

012-23 100 μg
EUR 255.96

prepro-Corticotropin-Lipotropin (108-120)

029-54 100 μg
EUR 214.92

Resistin (51-108) (Human) - Antibody

H-028-40 50 μl
EUR 604.8

Transmembrane Protein 108 (TMEM108) Antibody

abx034435-100g 100 µg
EUR 250

Adiponectin (108-244 a.a.) Protein

abx261717-05mg 0.5 mg
EUR 3650

Adiponectin (108-244 a.a.) Protein

abx261717-150g 150 µg
EUR 325

Adiponectin (108-244 a.a.) Protein

abx261717-50g 50 µg
EUR 225

Transmembrane Protein 108 (TMEM108) Antibody

abx238746-100l 100 µl Ask for price

Transmembrane Protein 108 (TMEM108) Antibody

abx238746-50l 50 µl
EUR 350

MV1LU CELLS 96 WELL/ 96 FILL

58-9696B each Ask for price
Description: flask ; Single or Mixed

CometAssay 96

4253-096-K 96 tests
EUR 513.6

Diethylsilane 96%

D24635 5G
EUR 338.11

Decaborane 96%

D00150 1G
EUR 308.12

Butyroin 96%

B31520 10G
EUR 204.72

Benzazimide 96%

B01380 5G
EUR 91.56

Indoline 96%

I01740 100G
EUR 139

Hexachlorodisiloxane 96%

H02650 10G
EUR 644.19

Hexachloropropene 96%

H02770 5G
EUR 166.87

Methyldiethoxysilane 96%

M15885 1G
EUR 119.87

Methylenecyclobutane 96%

M16928 1G
EUR 802.95

Pinacolone 96%

P19520 25G
EUR 126.85

Phenyldichlorosilane 96%

P10770 5G
EUR 160.79

Combi 96

OD300-1PK 1 unit
EUR 6.97
Description: Combi 96

Combi 96

OD300R-1PK 1 unit
EUR 6.97
Description: Combi 96

Tetraphenylsilane 96%

T08670 5G
EUR 264.69

Tetrabromocatechol 96%

T01850 5G
EUR 157.61

Triphenylsilane 96%

T30895 5G
EUR 138.67

Trimethylacetaldehyde 96%

T26315 5G
EUR 298.85

Targaprimir-96

T13085-10mg 10mg Ask for price
Description: Targaprimir-96

Targaprimir-96

T13085-1g 1g Ask for price
Description: Targaprimir-96

Targaprimir-96

T13085-1mg 1mg Ask for price
Description: Targaprimir-96

Targaprimir-96

T13085-50mg 50mg Ask for price
Description: Targaprimir-96

Targaprimir-96

T13085-5mg 5mg Ask for price
Description: Targaprimir-96

SP-96

T41256-10mg 10mg Ask for price
Description: SP-96

SP-96

T41256-1g 1g Ask for price
Description: SP-96

SP-96

T41256-1mg 1mg Ask for price
Description: SP-96

SP-96

T41256-50mg 50mg Ask for price
Description: SP-96

SP-96

T41256-5mg 5mg Ask for price
Description: SP-96

CFTR (108-117), Pseudomonas aeruginosa Inhibitor

5-00965 4 x 5mg Ask for price

Polyclonal MAGE12 / MAGEA12 Antibody (aa96-108)

APR02325G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MAGE12 / MAGEA12 (aa96-108). This antibody is tested and proven to work in the following applications:

Human Angiogenin 108-123 aa peptide

ANGN108-P 1 mg
EUR 343.2

MHC I(108-2C5), 0.2mg/mL

BNUB1095-100 100uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

MHC I(108-2C5), 0.2mg/mL

BNUB1095-500 500uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

MHC I(108-2C5), 1mg/mL

BNUM1095-50 50uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

IGKV1OR2-108 ORF Vector (Human) (pORF)

ORF021673 1.0 ug DNA Ask for price

Petri SealÒ Diameter : 0.5 X 108',

LA311-1NO 1 unit
EUR 153.48
Description: Petri SealÒ Diameter : 0.5 X 108',

Anti-beta synuclein (108-125) Antibody

Y075108 100 µl
EUR 535

Recombinant HBV PreS1 (aa 1-108)

VAng-Lsx0186-1mg 1 mg
EUR 4377.6
Description: HBV PreS1 (aa 1-108), recombinant protein from E. coli.

Recombinant Human Adiponectin (108-244 a.a.)

cyt-073-1mg 1mg
EUR 2700

Recombinant Human Adiponectin (108-244 a.a.)

cyt-073-25g 25µg
EUR 145

Recombinant Human Adiponectin (108-244 a.a.)

cyt-073-5g 5µg
EUR 60

DAT-108-619-10 AB Labels

027308 Pack of 10000 Label(s)
EUR 274.34
Description: Description Dutch: DaTab Dot Matrix Beprintbare Labels; Description French: Etiquettes Dot Matrix DaTab

XSL-108-461 AF Systems Consumables

060932 Roll of 500 Label(s)
EUR 59.3
Description: Description Dutch: LABXPERT & IDXPERT Labels; Description French: Etiquettes LABXPERT & IDXPERT

PTL-108-461 AF Systems Consumables

089409 Roll of 750 Label(s)
EUR 56.33
Description: Description Dutch: Zelflaminerende polyesterlabels voor M611, BMP61 en BMP71; Description French: Étiquettes auto-protégées en polyester pour M611, BMP61 et BMP71

WFDC-1 (63-108) Amide (Human)

012-73 100 μg
EUR 595.08

Prokineticin 2 (PK2) (82-108) (Human)

023-58 100 μg
EUR 282.96

[Cys0]-BAFF-R (108-129) (Human)

030-52 100 μg
EUR 177.12

prepro-Augurin (108-132) (Human) - Antibody

H-012-23 100 μl
EUR 370.44

OBAP / NDFUV3 (85-108) (Human) - Antibody

H-055-52 50 μl
EUR 604.8

Goat anti-mAPCS (aa97-108) Antibody

dAP-2499 50ug
EUR 264.6

Adiponectin (108-244 a.a.) Human Recombinant

rAP-0282 Inquiry Ask for price

miRZip-96 anti-miR-96 microRNA construct

MZIP96-PA-1 Bacterial Streak
EUR 620

H&V MIX CELLS MWP 96/96 FILL

98-9696 each Ask for price
Description: Single or Mixed

Lipocalin-2 (96-143) / NGAL (96-143) (Human)

013-41 100 μg
EUR 395.28

VERO W96/96

84-9696 each Ask for price
Description: flask ; Single or Mixed ; FreshFrozen

BGMK W96/96

53-9696 each Ask for price
Description: flask ; Single or Mixed ; FreshFrozen

3-Acetylcoumarin 96%

A07933 5G
EUR 102.88

Acetyl fluoride 96%

A08480 10G
EUR 698.75

Allene 96%_x000D__x000D_

A13440 25G
EUR 821.58

Acetonylacetone 96%_x000D__x000D_

A04660 100G
EUR 158.1

Acryloyl chloride 96%

A11230 5G
EUR 361.71

96-Well Plate

1996-2 each
EUR 124.8

96-Well CometSlides

4253-096-03 1 Tests
EUR 170.88

Formic Acid 96%

40100321-1 500 mL
EUR 40

Formic Acid 96%

40100321-2 1 L
EUR 61.76

2,2-Diphenylpropane 96%

D52010 5G
EUR 756.83

Dodecamethylene Glycol 96%

D55920 1G
EUR 156.19

1-Ethylcyclohexanol 96%

E06995 5G
EUR 435.77

Ethylhydrocupreine hydrochloride 96%

E10890 100MG
EUR 258.5

4-Ethylpyridine 96%

E14570 25G
EUR 223.28

Saturation of tumor uptake at a high dose of Ec1 in SKOV-3 model provided a rationale for dose selection in further studies using therapeutic conjugates of Ec1 for targeted therapy. In conclusion, [125I]I-PIB-Ec1 is a promising agent for visualizing EpCAM expression in OC.

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